![]() ![]() The fronto-temporal approach was the most common approach for resecting tumors located in the parasellar region (25/58 cases, 43.1%), while the temporo-occipital approach was conducted most commonly in the malignant group (76/299 cases, 25.4%). In the benign group, GTR was performed in all the patients with osteoma but in only 1/5 of the patients with myxoma because of the local invasion (Additional file 1: Table S1). After decades of development, multidisciplinary treatment consisting of surgical resection, radiotherapy, chemotherapy and comprehensive therapy has been achieved for previously inaccessible disorders. The preoperative/pathological diagnostic rate (PPDR) was 41.7% in the benign group, 69.9% in the malignant group, and 71.6% in the UNNT group (Additional file 1: Table S1). The parasellar region was more frequently associated with benign tumors (17/60 cases, 28.3%), while malignant tumors were found preferentially in the clivus (142/299 cases, 47.5%) and UNNTs tended to occur in the frontal bone (10/67 cases, 14.9% Additional file 1: Table S1). ![]() In regards to the clinicopathological characteristics, we found that the most common location was the clivus (169 cases, 39.7%), followed by parasellar (58 cases, 13.6%) and frontal (41 cases, 9.6%) regions (Fig. The age distribution of mortality had two peaks, one was between 11 and 30 years (11–20 years in male and 21–30 years in female), and the other was between 61 and 70 years (Fig. Similar to the incidence rate, the mortality rate was substantially higher in males than in females. Figure 1b showed that the maximum incidences of the patients with benign tumor, malignant tumor or UNNT were all in 31–40 age group. 1a, the incidence rate of all the cases increased rapidly until the age 40 years and the maximum incidence was in 31–40 age group accounted for 25.6% of the total cases. Majority of patients were adults (345 cases, 81.0%), which were about four times of pediatric patients (81 cases, 19.0%). There was a male preponderance (228 males and 198 females). The most common benign tumors and UNNTs were osteoma (13 cases, 3.1%) and fibrous dysplasia (FD 35 cases, 8.2%), respectively. The most frequent malignancy was chordoma (175 cases, 41.1%), which was the most common observed tumor types among all cases. Skull metastatic tumors occupied only a small percentage of this cohort (24 cases, 5.6%). Among all cases, 60 (14.1%) were diagnosed as benign tumors, 299 (70.2%) were malignant tumors and 67 (15.7%) were UNNTs (Additional file 1: Table S1). The mean age of the investigated patients was 33.0 years (range, 4–81 years). We, therefore, conducted this retrospective analysis on bony tumor spectrum involving the primary and secondary lesions arising from the skull to document the various types of tumors encountered, and to analyze their epidemiological characteristics, clinicopathogical features and neuroradiographic parameters.Ī total of 426 skull bone tumors including 27 subtypes diagnosed over a period of 10 years (from March 2005 to December 2016) were retrieved from the Sanbo Brain Hospital of the Capital Medical University (Beijing, China). Given the lack of literatures systematically reporting this uncommon disorder and the small-scale sample size published studies on these tumor entities, a deeper understanding of the clinicopathological features across skull bone tumor is necessary. ![]() According to the 2002 world health organization (WHO) histological typing, skull bone tumors can be divided into benign, malignant, and undefined neoplastic nature tumors (UNNTs). Skull bone tumors exist as a distinct entity because they include multiple subtypes, have complex regional anatomical structure, and require interdisciplinary therapy. ![]() Among the wide array of human neoplasms, bone and soft tissue tumors originating from the skull bone are extremely rare, making up < 2% of all the musculoskeletal tumors. ![]()
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